Scientific Program Advisory Committee (SPAC)

Program Chair

Laura Ranum, Ph.D.
Professor, Department of Molecular Genetics and Microbiology
University of Florida

Dr. Ranum’s group uses human genetics to define the molecular causes of neurological disorders (such as ataxia) and mouse models to understand how these mutations cause neurons in the brain to die. Her laboratory identified the myotonic dystrophy type 2 and spinocerebellar ataxia type 8 (SCA8) expansion mutations and developed mouse models of these diseases. In 2006, her group demonstrated the SCA8 expansion produces RNAs in both directions and in 2011 discovered “repeat associated non-AUG (RAN) translation”, a novel form of translation in which expansion mutations express proteins in all three reading frames without the canonical start codon. Additionally her group showed that RAN proteins accumulate in SCA8 and DM1 patient tissues.  Since that time, her group and other groups have shown RAN proteins also accumulate in C9orf72ALS/FTD and FXTAS. Dr. Ranum’s group is now focused on understanding the mechanisms of RAN translation and the impact of RAN proteins in neurological disease. 

Committee Members 

Chair

Laura Ranum, PhD
2016 - 2018
University of Florida

 

Henry Paulson, MD, PhD
2013 - 2016
University of Michigan
 

William Seeley, MD
2013 - 2016
University of California, San Francisco
 
Charlotte Sumner, MD
2013 - 2016
Johns Hopkins University 
Rebecca Gottesman, MD, PhD
2014 - 2017
Johns Hopkins University
Leigh Hochberg, MD, PhD
2014 - 2017
MGH/Harvard University/Brown University/Brigham&Women's/VA
 
Craig Powell, MD, PhD
2014 - 2017
University of Texas, Southwestern
Kevin Kerber, MD, MS
2015 - 2018
University of Michigan
Michael Racke, MD
2015 - 2018
Ohio State 
William Dauer, MD
2015 - 2018
University of Michigan 
 
Alica Goldman, MD, PhD, MS
2015 - 2018
Baylor University
M. Elizabeth Ross, MD, PhD
2015 - 2018
Weill Cornell Medical College